Frédéric Latour

Elucidating the cell circuitry in human epithelial cells and monocytes / macrophages that predispose to, or protect against, IBD

Patient blood, Lymphoblastoid cell lines (LCLs), or skin fibroblast cells are reprogrammed into hiPSC, and then differentiated in a stepwise fashion either into monocyte or macrophage cultures (top) or into 2D and 3D intestinal epithelial cultures (bottom). These models are used to evaluate the impact of genetic variants on structural and functional characteristics. We aim toContinue reading “Elucidating the cell circuitry in human epithelial cells and monocytes / macrophages that predispose to, or protect against, IBD”

Defining the Genes, Variants & Cells Involved in Crohn’s Disease and Ulcerative Colitis

Using a combination of genome-wide association, fine mapping, DNA sequencing and transcriptomic studies we aim to identify causal genes, their protective and predisposing variants, and biological contexts in which they exert their influences. (images from PMID: 25559196, 29420262, 36038634). We aim to define the rare and common variants, both coding and non-coding, that influence an individual’sContinue reading “Defining the Genes, Variants & Cells Involved in Crohn’s Disease and Ulcerative Colitis “