Archives de la catégorie : projects-fr

Using a combination of genome-wide association, fine mapping, DNA sequencing and transcriptomic studies we aim to identify causal genes, their protective and predisposing variants, and biological contexts in which they exert their influences.  (images from PMID: 25559196, 29420262, 36038634). We aim to define the rare and common variants, both coding and non-coding, that influence an individual’sLire la suite « Defining the Genes, Variants & Cells Involved in Crohn’s Disease and Ulcerative Colitis »

Patient blood, Lymphoblastoid cell lines (LCLs), or skin fibroblast cells are reprogrammed into hiPSC, and then differentiated in a stepwise fashion either into monocyte or macrophage cultures (top) or into 2D and 3D intestinal epithelial cultures (bottom). These models are used to evaluate the impact of genetic variants on structural and functional characteristics. We aim toLire la suite « Elucidating the cell circuitry in human epithelial cells and monocytes / macrophages that predispose to, or protect against, IBD »

We aim to unravel the biological heterogeneity of CD and UC using genetic, genomic and immunologic profiling of patient blood and stool samples and a subset with intestinal biopsies/surgical specimens, with a particular focus on incident cases of CD and in longitudinal studies of response to therapy in CD and UC. This enables us toLire la suite « Uncover the biological heterogeneity that is at the basis of clinical heterogeneity in IBD, and develop powerful diagnostic and prognostic biomarkers & tools. »