SELECTED RECENT PUBLICATIONS:
C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.
Mohanan V, Nakata T, Desch AN, Lévesque C, Boroughs A, Guzman G, Cao Z, Creasey E, Yao J, Boucher G, Charron G, Bhan AK, Schenone M, Carr SA, Reinecker HC, Daly MJ, Rioux JD, Lassen KG, Xavier RJ.
Science. 2018 Mar 9;359(6380):1161-1166. doi: 10.1126/science.aan0814. PMID: 29420262
Biomarker-guided stratification of autoimmune patients for biologic therapy.
Ivison S, Des Rosiers C, Lesage S, Rioux JD, Levings MK.
Curr Opin Immunol. 2017 Dec;49:56-63. doi: 10.1016/j.coi.2017.09.006. PMID: 29053992
Gélinas R, El Khoury N, Chaix MA, Beauchamp C, Alikashani A, Ethier N, Boucher G, Villeneuve L, Robb L, Latour F, Mondesert B, Rivard L, Goyette P, Talajic M, Fiset C, Rioux JD.
Circ Cardiovasc Genet. 2017 Oct;10(5). pii: e001755. doi: 10.1161/CIRCGENETICS.117.001755. PMID: 29021306
Fine-mapping inflammatory bowel disease loci to single-variant resolution.
Huang H, Fang M, Jostins L, Umićević Mirkov M, Boucher G, Anderson CA, Andersen V, Cleynen I, Cortes A, Crins F, D'Amato M, Deffontaine V, Dmitrieva J, Docampo E, Elansary M, Farh KK, Franke A, Gori AS, Goyette P, Halfvarson J, Haritunians T, Knight J, Lawrance IC, Lees CW, Louis E, Mariman R, Meuwissen T, Mni M, Momozawa Y, Parkes M, Spain SL, Théâtre E, Trynka G, Satsangi J, van Sommeren S, Vermeire S, Xavier RJ; International Inflammatory Bowel Disease Genetics Consortium, Weersma RK, Duerr RH, Mathew CG, Rioux JD, McGovern DPB, Cho JH, Georges M, Daly MJ, Barrett JC.
Nature. 2017 Jun 28. doi: 10.1038/nature22969. PMID: 28658209
Devalla HD, Gélinas R, Aburawi EH, Beqqali A, Goyette P, Freund C, Chaix MA, Tadros R, Jiang H, Le Béchec A, Monshouwer-Kloots JJ, Zwetsloot T, Kosmidis G, Latour F, Alikashani A, Hoekstra M, Schlaepfer J, Mummery CL, Stevenson B, Kutalik Z, de Vries AA, Rivard L, Wilde AA, Talajic M, Verkerk AO, Al-Gazali L, Rioux JD*, Bhuiyan ZA*, Passier R*. (#shared first authors; *co-corresponding authors)
EMBO Mol Med. 2016 Dec 1;8(12):1390-1408. doi: 10.15252/emmm.201505719. PMID: 27861123
A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis.
Rivas MA, Graham D, Sulem P, Stevens C, Desch AN, Goyette P, Gudbjartsson D, Jonsdottir I, Thorsteinsdottir U, Degenhardt F, Mucha S, Kurki MI, Li D, D'Amato M, Annese V, Vermeire S, Weersma RK, Halfvarson J, Paavola-Sakki P, Lappalainen M, Lek M, Cummings B, Tukiainen T, Haritunians T, Halme L, Koskinen LL, Ananthakrishnan AN, Luo Y, Heap GA, Visschedijk MC; UK IBD Genetics Consortium; NIDDK IBD Genetics Consortium, MacArthur DG, Neale BM, Ahmad T, Anderson CA, Brant SR, Duerr RH, Silverberg MS, Cho JH, Palotie A, Saavalainen P, Kontula K, Färkkilä M, McGovern DP, Franke A, Stefansson K, Rioux JD, Xavier RJ, Daly MJ.
Nat Commun. 2016 Sep 13;7:12869. doi: 10.1038/ncomms12869 PMID: 27619887
Sivanesan D, Beauchamp C, Quinou C, Lee J, Lesage S, Chemtob S, Rioux JD, Michnick SW.
J Biol Chem. 2016 Apr 15;291(16):8673-85. doi: 10.1074/jbc.M116.715870. Epub 2016 Feb 17. PMID: 26887945
Goyette P, Boucher G, Mallon D, Ellinghaus E, Jostins L, Huang H, Ripke S, Gusareva ES, Annese V, Hauser SL, Oksenberg JR, Thomsen I, Leslie S; International Inflammatory Bowel Disease Genetics Consortium; Australia and New Zealand IBDGC; Belgium IBD Genetics Consortium; Italian Group for IBD Genetic Consortium; NIDDK Inflammatory Bowel Disease Genetics Consortium; United Kingdom IBDGC; Wellcome Trust Case Control Consortium; Quebec IBD Genetics Consortium, Daly MJ, Van Steen K, Duerr RH, Barrett JC, McGovern DP, Schumm LP, Traherne JA, Carrington MN, Kosmoliaptsis V, Karlsen TH, Franke A, Rioux JD.
Nat Genet. 2015 Feb;47(2):172-9. doi: 10.1038/ng.3176. Epub 2015 Jan 5. PMID: 25559196
FOR A COMPLETE LIST OF PUBLICATIONS PLEASE CLICK HERE:
https://www.ncbi.nlm.nih.gov/pubmed/?term=rioux+jd
SELECTED ANNOUNCEMENTS:
June 2017 | Scientists zoom in on genetic culprits of IBD
March 2016 | Canada Foundation for Innovation awards $755,040 to create a platform in support of cellular and genomic medicine applications
March 2016 | CIHR awards $12.5 M for Patient Oriented Research in IBD and IBS
May 2014 | CIHR awards $2.5M to collaborative group to study the common role of LRRK2 Parkinson's disease, Crohn's disease, and leprosy
April 2013 | NIDDK Awards over $2M for defining the causality & biologic impact of genes within ulcerative colitis loci
April 2013 | Genome Canada and partners award $10M in support of the IBD Genomic Medicine Consortium (iGenoMed)
June 2010 | Canada Foundation for Innovation awards $487,947 to create Infrastructure in support of an integrative biology platform
October 2012 | Montreal-led research group awarded $1.8M from U.S. NIH
August 2011 | Multiple sclerosis research doubles numbers of associated genes
February 2011 | Research links 29 genome regions with common form of IBD
February 2010 | Research project on IBD to receive more than $2.3M from CIHR
February 2010 | New hope for patients with lactic acidosis
October 2009 | Two major projects are chosen by Pfizer-FRSQ Innovation Fund
January 2009 | MHI researchers contribute to identify new genetic markers for UC
August 2008 | Researchers discover new gene for Lupus and Rheumatoid Arthritis
June 2008 | Canadian researchers contribute to major Crohn's disease study
January 2008 | International Consortium find major genes for Lupus in women
April 2007 | Genome-wide study identifies major genes for Crohn's disease
January 2007 | Rioux and his team make list for Top Ten Discoveries of 2006
October 2006 | Scientists find gene target that may protect against IBD
September 2006 | International team analyzes genetic variation in key immune region