News

SELECTED RECENT PUBLICATIONS:

Fine-mapping inflammatory bowel disease loci to single-variant resolution.

Huang H, Fang M, Jostins L, Umićević Mirkov M, Boucher G, Anderson CA, Andersen V, Cleynen I, Cortes A, Crins F, D'Amato M, Deffontaine V, Dmitrieva J, Docampo E, Elansary M, Farh KK, Franke A, Gori AS, Goyette P, Halfvarson J, Haritunians T, Knight J, Lawrance IC, Lees CW, Louis E, Mariman R, Meuwissen T, Mni M, Momozawa Y, Parkes M, Spain SL, Théâtre E, Trynka G, Satsangi J, van Sommeren S, Vermeire S, Xavier RJ; International Inflammatory Bowel Disease Genetics Consortium, Weersma RK, Duerr RH, Mathew CG, Rioux JD, McGovern DPB, Cho JH, Georges M, Daly MJ, Barrett JC.

Nature. 2017 Jun 28. doi: 10.1038/nature22969. PMID: 28658209

 

TECRL, a new life-threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT.

Devalla HD#, Gélinas R#, Aburawi EH, Beqqali A, Goyette P, Freund C, Chaix MA, Tadros R, Jiang H, Le Béchec A, Monshouwer-Kloots JJ, Zwetsloot T, Kosmidis G, Latour F, Alikashani A, Hoekstra M, Schlaepfer J, Mummery CL, Stevenson B, Kutalik Z, de Vries AA, Rivard L, Wilde AA, Talajic M, Verkerk AO, Al-Gazali L, Rioux JD*, Bhuiyan ZA*, Passier R*. (#shared first authors; *co-corresponding authors)

EMBO Mol Med. 2016 Dec 1;8(12):1390-1408. doi: 10.15252/emmm.201505719. PMID: 27861123

 

A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis.

Rivas MA, Graham D, Sulem P, Stevens C, Desch AN, Goyette P, Gudbjartsson D, Jonsdottir I, Thorsteinsdottir U, Degenhardt F, Mucha S, Kurki MI, Li D, D'Amato M, Annese V, Vermeire S, Weersma RK, Halfvarson J, Paavola-Sakki P, Lappalainen M, Lek M, Cummings B, Tukiainen T, Haritunians T, Halme L, Koskinen LL, Ananthakrishnan AN, Luo Y, Heap GA, Visschedijk MC; UK IBD Genetics Consortium; NIDDK IBD Genetics Consortium, MacArthur DG, Neale BM, Ahmad T, Anderson CA, Brant SR, Duerr RH, Silverberg MS, Cho JH, Palotie A, Saavalainen P, Kontula K, Färkkilä M, McGovern DP, Franke A, Stefansson K, Rioux JD, Xavier RJ, Daly MJ.

Nat Commun. 2016 Sep 13;7:12869. doi: 10.1038/ncomms12869 PMID: 27619887

 

IL23R (Interleukin 23 Receptor) Variants Protective against Inflammatory Bowel Diseases (IBD) Display Loss of Function due to Impaired Protein Stability and Intracellular Trafficking.

Sivanesan D, Beauchamp C, Quinou C, Lee J, Lesage S, Chemtob S, Rioux JD, Michnick SW.

J Biol Chem. 2016 Apr 15;291(16):8673-85. doi: 10.1074/jbc.M116.715870. Epub 2016 Feb 17. PMID: 26887945

 

High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.

Goyette P, Boucher G, Mallon D, Ellinghaus E, Jostins L, Huang H, Ripke S, Gusareva ES, Annese V, Hauser SL, Oksenberg JR, Thomsen I, Leslie S; International Inflammatory Bowel Disease Genetics Consortium; Australia and New Zealand IBDGC; Belgium IBD Genetics Consortium; Italian Group for IBD Genetic Consortium; NIDDK Inflammatory Bowel Disease Genetics Consortium; United Kingdom IBDGC; Wellcome Trust Case Control Consortium; Quebec IBD Genetics Consortium, Daly MJ, Van Steen K, Duerr RH, Barrett JC, McGovern DP, Schumm LP, Traherne JA, Carrington MN, Kosmoliaptsis V, Karlsen TH, Franke A, Rioux JD.

Nat Genet. 2015 Feb;47(2):172-9. doi: 10.1038/ng.3176. Epub 2015 Jan 5. PMID: 25559196

 

FOR A COMPLETE LIST OF PUBLICATIONS PLEASE CLICK HERE:

https://www.ncbi.nlm.nih.gov/pubmed/?term=rioux+jd

 

SELECTED ANNOUNCEMENTS:

June 2017  | Scientists zoom in on genetic culprits of IBD

March 2016  | Canada Foundation for Innovation awards $755,040 to create a platform in support of cellular and genomic medicine applications

March 2016  | CIHR awards $12.5 M for Patient Oriented Research in IBD and IBS

May 2014  | CIHR awards $2.5M to collaborative group to study the common role of LRRK2  Parkinson's disease, Crohn's disease, and leprosy

April 2013  | NIDDK Awards over $2M for defining the causality & biologic impact of genes within ulcerative colitis loci

April 2013  | Genome Canada and partners award $10M in support of the IBD Genomic Medicine Consortium (iGenoMed)

June 2010  | Canada Foundation for Innovation awards $487,947 to create Infrastructure in support of an integrative biology platform

October 2012  | Montreal-led research group awarded $1.8M from U.S. NIH

August 2011  |  Multiple sclerosis research doubles numbers of associated genes

February 2011  |  Research links 29 genome regions with common form of IBD

February 2010  |  Research project on IBD to receive more than $2.3M from CIHR

February 2010  |  New hope for patients with lactic acidosis

October 2009  |  Two major projects are chosen by Pfizer-FRSQ Innovation Fund

January 2009  | MHI researchers contribute to identify new genetic markers for UC

August 2008  | Researchers discover new gene for Lupus and Rheumatoid Arthritis

June 2008  |  Canadian researchers contribute to major Crohn's disease study

January 2008  | International Consortium find major genes for Lupus in women

April 2007  | Genome-wide study identifies major genes for Crohn's disease

January 2007  |  Rioux and his team make list for Top Ten Discoveries of 2006

October 2006  |  Scientists find gene target that may protect against IBD

September 2006  | International team analyzes genetic variation in key immune region