Functional screen of inflammatory bowel disease genes reveals key epithelial functions.

Ntunzwenimana JC, Boucher G, Paquette J, Gosselin H, Alikashani A, Morin N, Beauchamp C, Thauvette L, Rivard MÈ, Dupuis F, Deschênes S, Foisy S, Latour F, Lavallée G, Daly MJ, Xavier RJ; iGenoMed Consortium, Charron G, Goyette P, Rioux JD.

Genome Med. 2021 Nov 11;13(1):181. doi: 10.1186/s13073-021-00996-7.  PMID: 34758847


Serum analyte profiles associated with Crohn’s disease and disease location.

Boucher G, Paradis A, Chabot-Roy G, Coderre L, Hillhouse EE, iGenoMed Consortium, Bitton A, Des Rosiers C, Levings MK, NIDDK IBD Genetics Consortium, Schumm P, Lazarev M, Brant SR, Duerr R, McGovern D, Silverberg MS, Cho J, Lesage S, Rioux JD.

Inflamm Bowel Dis. 2021 Jun 9:izab123. doi: 10.1093/ibd/izab123.  PMID: 34106269


A transcriptome-based approach to identify functional modules within and across primary human immune cells.

Mola S, Foisy S, Boucher G, Major F, Beauchamp C, Karaky M, Goyette P, Lesage S, Rioux JD.

PLoS One. 2020 May 29;15(5):e0233543. doi: 10.1371/journal.pone.0233543. PMID: 32469933


C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.

Mohanan V, Nakata T, Desch AN, Lévesque C, Boroughs A, Guzman G, Cao Z, Creasey E, Yao J, Boucher G, Charron G, Bhan AK, Schenone M, Carr SA, Reinecker HC, Daly MJ, Rioux JD, Lassen KG, Xavier RJ.

Science. 2018 Mar 9;359(6380):1161-1166. doi: 10.1126/science.aan0814. PMID: 29420262


Biomarker-guided stratification of autoimmune patients for biologic therapy.

Ivison S, Des Rosiers C, Lesage S, Rioux JD, Levings MK.

Curr Opin Immunol. 2017 Dec;49:56-63. doi: 10.1016/j.coi.2017.09.006. PMID: 29053992





November 2021  | Fighting gut infections contributes to preventing Crohn’s disease and ulcerative colitis

July 2021  | CIHR awards $691K to identify and functionally validate IBD genes and variants impacting intestinal epithelial barrier integrity

July 2021  | Genome Québec awards $199K to develop an inexpensive blood-based diagnostic test for Crohn’s Disease

January 2019  | Pfizer Canada Inc. awards  $151K for a prospective study of immune cell responsiveness to understand drug response in UC patients treated with tofacitinib

September 2018  | NIH awards $600K USD to understand how a loss of epigenetic reader SP140 contributes to IBD

September 2018  | The CIHR Human Immunology Initiative awards $1.5M to The Canadian Autoimmunity Standardization Core (CAN-ASC)

June 2017  | Scientists zoom in on genetic culprits of IBD

March 2016  | Canada Foundation for Innovation awards $755,040 to create a platform in support of cellular and genomic medicine applications

March 2016  | CIHR awards $12.5 M for Patient Oriented Research in IBD and IBS

May 2014  | CIHR awards $2.5M to collaborative group to study the common role of LRRK2  Parkinson's disease, Crohn's disease, and leprosy

April 2013  | NIDDK Awards over $2M for defining the causality & biologic impact of genes within ulcerative colitis loci

April 2013  | Genome Canada and partners award $10M in support of the IBD Genomic Medicine Consortium (iGenoMed)

June 2010  | Canada Foundation for Innovation awards $487,947 to create Infrastructure in support of an integrative biology platform

October 2012  | Montreal-led research group awarded $1.8M from U.S. NIH

August 2011  |  Multiple sclerosis research doubles numbers of associated genes

February 2011  |  Research links 29 genome regions with common form of IBD

February 2010  |  Research project on IBD to receive more than $2.3M from CIHR

February 2010  |  New hope for patients with lactic acidosis

October 2009  |  Two major projects are chosen by Pfizer-FRSQ Innovation Fund

January 2009  | MHI researchers contribute to identify new genetic markers for UC

August 2008  | Researchers discover new gene for Lupus and Rheumatoid Arthritis

June 2008  |  Canadian researchers contribute to major Crohn's disease study

January 2008  | International Consortium find major genes for Lupus in women

April 2007  | Genome-wide study identifies major genes for Crohn's disease

January 2007  |  Rioux and his team make list for Top Ten Discoveries of 2006

October 2006  |  Scientists find gene target that may protect against IBD

September 2006  | International team analyzes genetic variation in key immune region