Project Summary: At the core of the iGenoMed-MTT Project is a multi-center prospective clinical study of response to advanced therapies in IBD. Biological samples are taken just prior to initiation of a Molecularly Targeted Therapy or MTT as well as at the first follow-up visit when an individual’s response is assessed. In this study, patients are followed for a year. Should a patient fail to respond to a therapy and is prescribed a new MTT by their physician, they are invited to rejoin the study. In this way, we hope to be able to follow patients in their journey to find the most effective therapy. Our Team applies state-of-the-art genetic, proteomic, metabolomic, transcriptomic, immune status & response, and microbiome analyses to obtain a comprehensive analysis of a patients biological status to better understand why some patients respond to their medication whereas others do not. The objective is to develop personalized medicine tools to match patients to the most effective therapy, and to identify novel targets for the development of effective therapies.
THE TEAM:
IBD Genomic Medicine Consortium (MTT Study Team):
Robert Battat1, Alain Bitton2, Karine Tremblay3, Julie Thompson Legault4, Gabrielle Boucher4, Virginie Mercier4, Marie-Ève Rivard4, Pierre Poitras1, Justin Côté-Daigneault1, Katarzyna Orlicka1, Audrey Weber1, Benoît Panzini1, Edmond-Jean Bernard1, Érik Deslandres1, Louise D’Aoust1, Michel Boivin1, Michel Lemoyne1, Mickael Bouin1, Raymond Lahaie1, Raymond Leduc1, Simon Bouchard1, Alexia Monges1, Nancy Nadeau1, Stéphanie Côté-Daigneault1, Aimélie Bilodeau1, Louise Merly1, Karine Paupert1, Inès Ouchetati1, Bob Useni1, Marie-Pier Verpaelst1, Gary Wild2, Peter Lakatos2, Talat Bessissow2, Waqqas Afif2, Ernest Seidman2, Rita Kohen2, Kayleigh Morris2, Carolyne Lemieux2, Myriam Ouellette-Cabana2, Sakina Bennaghmouch2, Alban Michaud-Herbst3, Laurie Morin3, Jean-Maxime Picard3, Laurence Tessier3, Anne-Pascale Tremblay3, Joanie Bouchard3, John D. Rioux4
1 Centre Hospitalier de l’Université de Montréal, Montréal, Quebec, Canada; 2 McGill University Health Centre, Montreal, Quebec, Canada;3 CIUSSS Saguenay—Lac-Saint-Jean, Chicoutimi, Québec, Canada; 4 Montreal Heart Institute and Université de Montréal, Montréal, Quebec, Canada;